Re: More various

1

The transparent brains are so awesome. Be sure to click through and watch the video. it's f'in' amazing.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 8:48 AM
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It was the same video as before. Then it wasn't.


Posted by: Moby Hick | Link to this comment | 04-16-13 8:51 AM
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Tweety and I recently watched Singin' in the Rain, and my first reaction to the Keller/Sullivan clip was that wow, SitR really did a good job capturing the timbre and cadences of early sound film.


Posted by: Blume | Link to this comment | 04-16-13 9:12 AM
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Brain, brain, brain, brain, brain, brain, brain. Narf!


Posted by: Ginger Yellow | Link to this comment | 04-16-13 9:28 AM
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I tried and failed to come up with a "pinkeye and the brainsplosion" joke in that recent thread.


Posted by: Eggplant | Link to this comment | 04-16-13 9:32 AM
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||
Lee is currently waiting for the phone to ring for her screening interview for a good job much like her last one. I am trying to be cool about this because I don't want to stress her, but oh my goodness I hope she just gets a fucking job. But a good one that pays well and will not make her miserable would be nice. Yesterday had good progress on the sticking-it-to-the-former-job front, but I could really use a little more security about likely futures than I have right now.
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Posted by: Thorn | Link to this comment | 04-16-13 9:35 AM
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Did they combine the transparent brain with the system that makes neurons light up when they fire? Peeow! Peeow!


Posted by: SP | Link to this comment | 04-16-13 9:37 AM
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I love it when things like that video turn out to exist, things you just would have imagined didn't. There are sound recordings of Sarah Bernhardt and Tolstoy, you know?

(One thing I always hope I'll find or stumble upon is film of Dorothy Parker. I'm always curious what she sounded like when not simultaneously drawling and over-enunciating for the recording horn. She must have been interviewed on tv at some point...)


Posted by: Mister Smearcase | Link to this comment | 04-16-13 9:45 AM
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Did you read that thing by the super-entitled and super-whiny Princeton mom? Want something even worse? Meet the SWUGs!

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Posted by: Cryptic ned | Link to this comment | 04-16-13 9:47 AM
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6: Good luck to Lee.


Posted by: Moby Hick | Link to this comment | 04-16-13 9:53 AM
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8: Wonder no more!


Posted by: Ginger Yellow | Link to this comment | 04-16-13 9:54 AM
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This recreation of an Emile Berliner recording from 1889 -- recreated from an engraving -- blew my mind.


Posted by: snarkout | Link to this comment | 04-16-13 10:00 AM
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Thanks, Moby. The interview went fine and they were asking about things she can speak to well. She interviews well, so I'm feeling a big sense of relief now. It's just good to know that there are options out there sometimes, even if she doesn't get this one.


Posted by: Thorn | Link to this comment | 04-16-13 10:01 AM
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Nice video. Rare? Not any more.


Posted by: bingobangoboy | Link to this comment | 04-16-13 10:12 AM
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Dammit. The transparent brain thing is way cooler than the Helen Keller thing. There's a video at the link! It's uh-maaaaazing!


Posted by: Sifu Tweety | Link to this comment | 04-16-13 10:16 AM
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More food porn.


Posted by: Opinionated Zombie | Link to this comment | 04-16-13 10:17 AM
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That SWUG thing is completely unobjectionable. Raisa Bruner wrote an article for a school paper about the differing social positions of freshman and senior women and people are freaking out.


Posted by: lemmy caution | Link to this comment | 04-16-13 10:20 AM
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9: Why is the piece about the SWUGs worse? Sounds to me like they're just going through a phase (an alcohol-drenched, highly negative phase perhaps) - kind of a senior slump. Easier for me to take than "that thing by the [aptly-described] super-entitled and super-whiny Princeton mom."

On preview, massively, nay, heroically pwned by 17.


Posted by: bill | Link to this comment | 04-16-13 10:25 AM
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Anyhow to respond to 7 that would be difficult, since the transparentifying process involves taking the brain out of the animal, which greatly reduces brain activity. But you totally can stain different types of neruons and have them show up when everything else is transparent.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 10:25 AM
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taking the brain out of the animal, which greatly reduces brain activity

Also, makes it hard for those involved to date PETA members.


Posted by: Moby Hick | Link to this comment | 04-16-13 10:27 AM
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I mean it doesn't have to be a living animal; some of the tests they did were on brains of deceased people that were in brain banks.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 10:33 AM
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But again, brain activity in dead animals is greatly reduced.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 10:34 AM
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Reduced, but sometimes still statistically significant.


Posted by: Eggplant | Link to this comment | 04-16-13 10:36 AM
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24

The brain video was awesome but I don't just want to go inside a mouse's brain, I want to really get inside the mind of a mouse.


Posted by: Robert Halford | Link to this comment | 04-16-13 10:36 AM
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23: if you measure it wrong, yes.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 10:37 AM
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The last mouse I saw was one that ran into a plastic tray full of glue. Why don't you try that.


Posted by: Moby Hick | Link to this comment | 04-16-13 10:38 AM
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Is there any point to the article in 9 other than to sate our eternal curiosity about how -- and I mean EXACTLY how -- 21 year olds are having sex?


Posted by: Robert Halford | Link to this comment | 04-16-13 10:40 AM
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Not as cool as the transparent brains video, but magnetic putty is pretty captivating.


Posted by: apostropher | Link to this comment | 04-16-13 10:50 AM
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27: Don't they have sex the same way as everyone else? (Everyone but urple, of course.)


Posted by: Stanley | Link to this comment | 04-16-13 10:50 AM
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29: Yep. One leg at a time.


Posted by: apostropher | Link to this comment | 04-16-13 10:56 AM
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Or maybe that's putting on pants after sex. 21 was a really long time ago for some of us.


Posted by: apostropher | Link to this comment | 04-16-13 10:56 AM
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I love it when things like that video turn out to exist, things you just would have imagined didn't. There are sound recordings of Sarah Bernhardt and Tolstoy, you know?

Yes! And footage of Anna Pavlova dancing.


Posted by: Blume | Link to this comment | 04-16-13 11:10 AM
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The brain video is pretty awesome. Now I want someone to make pretty videos explaining my papers with an English accent.


Posted by: essear | Link to this comment | 04-16-13 11:41 AM
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So should Obama just give all that brain-mapping money to these people at Stanford? Seems way beyond the one cubic millimeter of mapped mouse neurons or whatever it was that people were touting before.


Posted by: essear | Link to this comment | 04-16-13 11:44 AM
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34: I hope he withholds judgment until they can prove that the transparent mice brains still have satisfying orgasms.


Posted by: Natilo Paennim | Link to this comment | 04-16-13 12:05 PM
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Do you think heebie and Cala are having babies right now?


Posted by: oudemia | Link to this comment | 04-16-13 12:19 PM
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A babysplosion-once-removed friend of mine just had hers yesterday. I'm all excited; they live a block away and I'm hoping to get to babysit.


Posted by: LizardBreath | Link to this comment | 04-16-13 12:20 PM
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And heebie was sending non-baby-related emails a half hour ago, so probably not for her at least.


Posted by: LizardBreath | Link to this comment | 04-16-13 12:21 PM
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38: Multitasking?


Posted by: oudemia | Link to this comment | 04-16-13 12:24 PM
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34: nooo he should give it all to me.

(In all serious there are lots of pieces of a "map of the brain" that this approach can't help with -- notably what happens when it's actually powered up and doing things. But it is really astounding, and has the potential to increase understanding very, very rapidly. N.B. the same lab discovered optogenetics, which means they are the most badass neuroscience lab there is. Deisseroth has to be kind of a presumptive Nobelist at this point.)


Posted by: Sifu Tweety | Link to this comment | 04-16-13 12:25 PM
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Could be.

Funny note on Lamaze breathing -- we were talking here about how lots of us still haul it out to deal with anticipated pain. My mother just mentioned this weekend that she still uses it, almost fortytwo years since her last kid, for the same sorts of things.


Posted by: LizardBreath | Link to this comment | 04-16-13 12:26 PM
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(Oh also, the "map of the brain" idea that originally inspired the federal project is basically stupid, and there are actually a hell of a lot of things you'd want to know about the brain that are at best tangential to a full map of functional connectivity. Hopefully the money goes to worthwhile projects regardless of how tightly they fit that description. This is one of the many ways the analogy to the human genome project is flawed.)


Posted by: Sifu Tweety | Link to this comment | 04-16-13 12:27 PM
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Deisseroth has to be kind of a presumptive Nobelist at this point.

I suppose if you give someone a big award, they'll tend that way.


Posted by: Moby Hick | Link to this comment | 04-16-13 12:28 PM
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Not having the baby. Teaching classes. Whenever I'm queen of the world and pass laws related to maternity leave, everyone gets 36w-delivery off of work because man this last month has been uncomfortable and also I have only three work-appropriate shirts that fit.


Posted by: Cala | Link to this comment | 04-16-13 12:44 PM
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Dammit. The transparent brain thing is way cooler than the Helen Keller thing. There's a video at the link! It's uh-maaaaazing!

I can't believe you're attacking Helen Keller. Who does that?


Posted by: beamish | Link to this comment | 04-16-13 12:44 PM
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44: I totally remember that racing to the finish line feeling, wondering if I was going to have the baby before I was bigger than all of my clothes.


Posted by: LizardBreath | Link to this comment | 04-16-13 12:48 PM
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38: Multitasking?

Blame the advent of the iPad.


Posted by: knecht ruprecht | Link to this comment | 04-16-13 12:51 PM
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46: And honestly, what the hell is up with that? I look like I have a basketball under my clothes. Many women carry a lot bigger than I am; why are these shirts not five inches longer?


Posted by: Cala | Link to this comment | 04-16-13 12:51 PM
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49

45: a lot of people, in her lifetime.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 12:52 PM
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why are these shirts not five inches longer?

If we could add five inches of material to the maternity shirts of every pregnant woman of unfogged, the mills of Lancashire would be kept busy for a century.


Posted by: knecht ruprecht | Link to this comment | 04-16-13 12:55 PM
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51

Shit. I hadn't realized that I was echoing a line from the other thread. I'm sorry.


Posted by: beamish | Link to this comment | 04-16-13 1:14 PM
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The YouTube link wasn't showing up at first—it was just a dark rectangle, so I thought heebs was just making a Helen Keller joke.

Apropos, have you ever seen a map of Helen Keller's brain? Neither has she! Har.


Posted by: Jesus McQueen | Link to this comment | 04-16-13 1:16 PM
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"What's on your mind,"
he asked, "my dear?"
"Why can't you see?
It's crystal clear.
Now all my thoughts must be apparent.
They've fixed my brain to be transparent."


Posted by: wrenae | Link to this comment | 04-16-13 1:18 PM
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I'm here, too. Although I told everyone I'd be unavailable after April 6th, so I've packed up all my work maternity clothes and good fucking riddance to them, too.


Posted by: heebie-geebie | Link to this comment | 04-16-13 1:24 PM
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51: if that was to me, I actually laughed, so don't worry. But then, history's greatest monster, &c.


Posted by: x.trapnel | Link to this comment | 04-16-13 1:26 PM
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56

History's greatest monster is the guy who came up with the "when the leash goes slack" joke.


Posted by: Moby Hick | Link to this comment | 04-16-13 1:30 PM
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Or Hitler. You can never rule him out in that sort of contest.


Posted by: Moby Hick | Link to this comment | 04-16-13 1:35 PM
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44, 54: One of you two has to live blog labor and delivery. We've had lots of fun live events here, but not that one yet.


Posted by: rob helpy-chalk | Link to this comment | 04-16-13 1:46 PM
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UNGGGGGGGGGH


Posted by: Robert Halford | Link to this comment | 04-16-13 1:58 PM
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60

Halford beat us to it.


Posted by: heebie-geebie | Link to this comment | 04-16-13 2:00 PM
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the same lab discovered optogenetics,

I'm trying to piece together what this is based on the wikipedia article and linked sources. So they insert a gene for a light-sensitive protein into an animal's brain. Are they doing this with a virus, just infecting all of an adult animal's brain cells? Then they use a laser to stimulate this light-sensitive protein in a particular neuron. Does that mean they have some sort of nanoprobe which gives of laser light jammed into the cell? Then they use the laser to stimulate the cell and observe the results. So they can, like, make the cell give off different chemicals and see what kind of signaling pathways are activated?


Posted by: rob helpy-chalk | Link to this comment | 04-16-13 2:09 PM
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49: Indeed. Good read:
http://www.iww.org/en/history/library/HKeller/why_I_became_an_IWW

"The true task is to unite and organize all workers on an economic basis, and it is the workers themselves who must secure freedom for themselves, who must grow strong." Miss Keller continued. "Nothing can be gained by political action. That is why I became an IWW."

Posted by: Natilo Paennim | Link to this comment | 04-16-13 2:20 PM
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Helen Keller trivia! Did you know that she introduced Akitas to the US?


Posted by: Jesus McQueen | Link to this comment | 04-16-13 2:25 PM
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Some light reading: http://www.detaineetaskforce.org


Posted by: Katherine | Link to this comment | 04-16-13 2:26 PM
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Right -- I need to put up a post on that tonight/tomorrow.


Posted by: LizardBreath | Link to this comment | 04-16-13 2:30 PM
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61: you've pretty much got it. The light-sensitive ion channels can be injected selectively by using viruses (like rabies) that travel along synapses, and the chemicals that are being released are neurotransmitters, so you can selectively activate networks of neurons. Oh, and you don't need to put the light in the cell as the cells are translucent. In fact, you can just shine a light at the brain and get them to release that way.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 4:03 PM
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Er, shine a light at the surface of the brain, that is. Also, it's possible to get multiple different kinds of rhodopsin whatever to express in a cell, so that you can activate dopamine with a blue light and serotonin with a green light or whatever.

The big question a/f/a using it to study human cognition is if people will be able to get it to work in monkeys; right now it works in mice and rats (and maybe other species) but nobody has demonstrated it in primates.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 4:14 PM
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Haven't they also reversed it so that ion flux can result in light emission so you can track where the neurons fire?


Posted by: SP | Link to this comment | 04-16-13 4:19 PM
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The light-sensitive ion channels can be injected selectively by using viruses (like rabies) that travel along synapses

See, I'm just old enough to think this is creepy futuristic.


Posted by: rob helpy-chalk | Link to this comment | 04-16-13 4:20 PM
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68: I believe so, yeah. Although I'm not sure how fine-grained that is; I think most studies still use single-unit electrophysiology to record responses.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 4:24 PM
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69: oh my god it's totally creepy futuristic. It's also amazing, though.

Also, wait, using giant magnets cooled by liquid helium to measure the blood flow in every blood vessel in your brain at once (well, basically) isn't creepy futuristic?


Posted by: Sifu Tweety | Link to this comment | 04-16-13 4:25 PM
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Or what about MEG? That actually uses SQUIDs, as seen in the story Johnny Mnemonic.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 4:26 PM
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And they're a lot better than draining all of the CSF and then using super high powered x-rays. That shit is creepy Victorian.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 4:27 PM
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SQUIDs are pretty awesome.


Posted by: essear | Link to this comment | 04-16-13 4:33 PM
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Also the MEG is by far the most creepy-futuristic looking device known to science.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 4:50 PM
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76

Dancing is hard.


Posted by: Natilo Paennim | Link to this comment | 04-16-13 5:33 PM
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Excel error (partially) responsible for austerity.

Fucking Excel. Pretty much the first thing I did as a summer research assistant for [prominent economist] long ago was discover that his previous assistant had omitted one column when sorting a dataset in Excel for a draft NBER working paper. The seemingly large and highly statistically significant impact of the variable in that column did not survive the corrected sorting.

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Posted by: Mr. Blandings | Link to this comment | 04-16-13 6:00 PM
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Everybody should just go ahead and learn SAS.


Posted by: Moby Hick | Link to this comment | 04-16-13 6:12 PM
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Good luck birthing ladies! I hope those babies come quickly, easily, and safely!


Posted by: will | Link to this comment | 04-16-13 6:13 PM
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9: Meet the SWUGs!

"For the SWUG is not a type but an ethos," Taylor explains. "It is the Dionysian response to the cruel brevity of our bright college years. The SWUG seeks oblivion in the face of despair, love in the face of alienation, whiskey in the face of moving back in with your parents who don't have a liquor cabinet."

Oh, oh, oh!

Actually I didn't realize that Yale had frats.


Posted by: parsimon | Link to this comment | 04-16-13 6:20 PM
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81

The first fraternities in the US were at Yale.


Posted by: apostropher | Link to this comment | 04-16-13 6:28 PM
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Yale has over forty words for "fraternity".


Posted by: heebie-geebie | Link to this comment | 04-16-13 6:29 PM
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83

Stover at Yale!


Posted by: clew | Link to this comment | 04-16-13 6:34 PM
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84

Maybe someone should make a tv show that consists of exact, scriptural remakes of episodes of Golden Girls except everyone is college aged.


Posted by: fake accent | Link to this comment | 04-16-13 6:38 PM
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Either I'm really tired and kind of out of it or 84 is the most brilliant idea I've heard in months. Both, maybe.


Posted by: essear | Link to this comment | 04-16-13 6:43 PM
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85: I first read that as "most brilliant idea I've *had* in months," and thought, Wow! essear has really caught on! He's demanding to be co-author!


Posted by: oudemia | Link to this comment | 04-16-13 6:46 PM
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The many, many international versions of the Golden Girls are pretty awesome (get ready for "Las Chicas De Oro"). Dutch Blanche is pretty hot for an old Dutch woman.


Posted by: Robert Halford | Link to this comment | 04-16-13 6:48 PM
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The first fraternities in the US were at Yale.

I had no idea.

84 is indeed brilliant. But seriously, what is wrong with people (21-year-olds) that they're acting all world-weary and shit?

Buncha drama queens.


Posted by: parsimon | Link to this comment | 04-16-13 6:49 PM
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86: Hee!


Posted by: essear | Link to this comment | 04-16-13 6:52 PM
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As entertaining as your tv show ideas are, essear, I really have work to do.


Posted by: fake accent | Link to this comment | 04-16-13 6:55 PM
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81 is not actually true; depending on how you define "fraternity" the first was either at William and Mary in 1776 or Union College in 1825.


Posted by: teofilo | Link to this comment | 04-16-13 6:56 PM
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But Yale does have plenty of frats; George W. Bush was famously president of one.


Posted by: teofilo | Link to this comment | 04-16-13 6:56 PM
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93

I now have "Thank you for being a friend" (sung by Lenny) stuck in my head.


Posted by: fake accent | Link to this comment | 04-16-13 7:04 PM
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You want to replace that with a much better song that will not leave your head? The 1-minute snippet of the new Daft Punk is impossibly good.


Posted by: emdash | Link to this comment | 04-16-13 7:16 PM
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95

emdash!


Posted by: nosflow | Link to this comment | 04-16-13 7:51 PM
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Can I share my earworm? At least it's not We Built This City.


Posted by: CharleyCarp | Link to this comment | 04-16-13 7:58 PM
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Also about people in their 20s having sex; also vaguely depressing.

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Posted by: NickS | Link to this comment | 04-16-13 8:05 PM
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94: I had been skipping it because I wasn't sure I wanted to spoil it, but jesus christ that's good.


Posted by: Sifu Tweety | Link to this comment | 04-16-13 8:11 PM
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I don't like it! This makes me terribly sad.


Posted by: redfoxtailshrub | Link to this comment | 04-16-13 8:14 PM
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82: Yale has 40 words for snow but they all also mean "you are so iced, brah!"


Posted by: Mister Smearcase | Link to this comment | 04-16-13 9:01 PM
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I feel like I read Carmen Maura was going to be in the Spanish Golden Girls, which is a little sad for me since she is permanently Pepa Marcos in my universe.


Posted by: Mister Smearcase | Link to this comment | 04-16-13 9:04 PM
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95: Nosflow!

99: Alas!


Posted by: emdash | Link to this comment | 04-16-13 9:51 PM
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I presume 56 is a confession.

86: I read it the same way! Essear's using Science! to see into our brains and change our perceptions. I knew Science! would only be used for evil.


Posted by: Walt Someguy | Link to this comment | 04-16-13 11:55 PM
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Maybe someone should make a tv show that consists of exact, scriptural remakes of episodes of Golden Girls except everyone is college aged.

This reminds me of the sitcom idea set in an old folks home where all the inhabitants had known each other at college. Also an excellent concept.


Posted by: ajay | Link to this comment | 04-17-13 3:09 AM
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81 is not actually true

But it feels true. In my gut.


Posted by: apostropher | Link to this comment | 04-17-13 4:53 AM
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