Re: q12h

1

now, you shut your purty mouth about oxycodone! this addiction bullshit sucks, but a) those people would just be alcoholics otherwise, near as I can figure it and b) I see ZERO evidence anyone is over-prescribing these drugs. they are piss-testing my mom and she has stage IV lung cancer that metastasized to her brain. do they think she's in it for the sweet, sweet dope? then when she came up positive for morphine because my sister gave her some of her own instant release when mom was feeling awful, they wanted to cut back on my mom's drugs. did I tell you the part about where she has cancer? pain doctors can only have like 200 patients now, and often you literally can't find one at all. my sister's doc is a bitch who is sure that my sister is lying about the pain from her ehlers-dalnos and lupus and sjogren's syndrome and who cut her meds down by 75% with no warning or taper. there is nowhere else my sister can go and she's in agony now all the time. fuck that noise. and oxycontin doesn't even really get you high!?


Posted by: alameida | Link to this comment | 05- 8-16 6:22 AM
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The article's not badmouthing painkillers, it's badmouthing the drug company that insisted on preserving Oxy's competitive advantage as the painkiller that would work on a 12 hour schedule, by trying to keep doctors from prescribing it on a shorter schedule for patients who needed it more often. Which left lots of patients with, say, nine hours of pain relief, and then three hours of misery waiting for their next dose -- bad because (a) pain is bad, and (b) it's training them to crave the drug in a way that steady pain relief wouldn't.

Yay, painkillers! But boo, evil drug companies.


Posted by: LizardBreath | Link to this comment | 05- 8-16 6:33 AM
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OK it sounds more reasonable that way. [[wordlessly makes "I'm watching you" sign with forked fingers]]


Posted by: alameida | Link to this comment | 05- 8-16 7:03 AM
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I'm a highly trained "making things sound reasonable" professional.


Posted by: LizardBreath | Link to this comment | 05- 8-16 7:06 AM
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This is the first thing I've read that makes a really comprehensible argument about why there (seems to be) so much more addiction. Scary shit.


Posted by: Nathan Williams | Link to this comment | 05- 8-16 7:16 AM
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I saw this article a few days ago and my takeaway was LB's. My other takeaway was Burn Shit Down and Sow Salt in the Ruins levels of outrage.

Purdue tells doctors to prescribe stronger doses, not more frequent ones, when patients complain that OxyContin doesn't last 12 hours. That approach creates risks of its own. Research shows that the more potent the dose of an opioid such as OxyContin, the greater the possibility of overdose and death.
More than half of long-term OxyContin users are on doses that public health officials consider dangerously high, according to an analysis of nationwide prescription data conducted for The Times.

I hadn't realised it was an opioid. Should have guessed


Posted by: chris y | Link to this comment | 05- 8-16 7:46 AM
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my daughter's doc is prescribing multiple doses rather than increasing amounts, so, yay him I guess? girl x and I got no traction with him until we brought in husband x as official white university professor/colleague (she's at nuh); suddenly then it was OK.


Posted by: alameida | Link to this comment | 05- 8-16 7:59 AM
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Shouldn't be too hard to read between the lines and figure who I am, but my company has worked extensively with P/ur/d/ue and I can attest that 1) they are indeed ethically dodgy and a pain in the ass to work with, and 2) the FDA absolutely hates them.


Posted by: el presidente | Link to this comment | 05- 8-16 8:07 AM
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Not to put too fine a point on it, shouldn't misrepresenting facts relating to prescription opiates be the sort of thing that leads to fraud charges and executives going to prison? I mean, we aren't very relaxed about opiates in other respects, are we?


Posted by: Flippanter | Link to this comment | 05- 8-16 11:31 AM
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9 certainly seems right. Also that is excellent journalism. If it's accurate, it reveals that both the FDA and the DOJ were asleep for at least 15 years, and that there is basically no recourse other than crappy federal agencies for regulating this stuff.


Posted by: R Tigre | Link to this comment | 05- 8-16 11:47 AM
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Well, we've already established pharmaceutical execs will be first against the wall. I guess we know who will be right after Shk reli (he's still gonna be first).


Posted by: Buttercup | Link to this comment | 05- 8-16 12:31 PM
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||guys here is what I've learned. there is a movie where Mireille from French in Action gets totally nude. And the mime is for real Marion Cotillard's father|>


Posted by: R Tigre | Link to this comment | 05- 8-16 6:13 PM
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I'm glad your Google alerts are finally giving you useful news.


Posted by: Moby Hick | Link to this comment | 05- 8-16 6:35 PM
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I guess I've been assuming for some time now that if I ever get any kind of really excruciating illness, I'll just have to go on the street for whatever I can get to self-medicate.


Posted by: Natilo Paennim | Link to this comment | 05- 8-16 8:27 PM
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I am hoping readily available marijuana will be a new option for a meaningful number of people.


Posted by: Minivet | Link to this comment | 05- 8-16 8:33 PM
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14: It's looking good for Tigre's bet, then.


Posted by: ajay | Link to this comment | 05- 9-16 2:20 AM
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14: yeah it's frustrating to me and other family members than we had jobs, went to graduate school, and did many physically active things while smacked up, and sober now we all are miserable and can't do anything. no one wants to get driven into the arms of the pusherman because that's a horrible way to live, but sometimes when you think about how you used to have two jobs and tons of friends and went out, it makes sobriety seem unsatisfactory. the medical company that invented heroin for real made good on their promises; it kills pain stone dead. wait, except they lied about the possibility it would cause addiction. so, 50% right?


Posted by: alameida | Link to this comment | 05- 9-16 3:54 AM
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I think we need to subtract a bit for the Zyclon B they made during the war.


Posted by: Moby Hick | Link to this comment | 05- 9-16 4:14 AM
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Wiki reveals that heroin was first synthesised by a chemist in London but he couldn't see how it would be any use.


Posted by: ajay | Link to this comment | 05- 9-16 4:36 AM
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"How could we improve upon the perfection that is opium?"


Posted by: Moby Hick | Link to this comment | 05- 9-16 5:13 AM
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Further from Wiki, for the benefit of people in the reading group: apparently Bayer lost trademark rights to Heroin and Aspirin under the Treaty of Versailles. That's not just mean, it's a ridiculous level of micromanaging for an international treaty.


Posted by: chris y | Link to this comment | 05- 9-16 5:23 AM
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I wonder if Deluge will mention that?


Posted by: Moby Hick | Link to this comment | 05- 9-16 5:26 AM
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I don't recall seeing it there.


Posted by: chris y | Link to this comment | 05- 9-16 5:47 AM
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Really very informative and creative. This sharing concept is a good way to enhance the knowledge. Thank you very much for this post. I like this site very much.


Posted by: kaashvimohan | Link to this comment | 05- 9-16 6:04 AM
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21: On the other hand, fuck the Kaiser.


Posted by: Flippanter | Link to this comment | 05- 9-16 6:16 AM
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I think comments like 25 are damaging to the high regard which spam bots hold for this blog.


Posted by: Moby Hick | Link to this comment | 05- 9-16 6:21 AM
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apparently Bayer lost trademark rights to Heroin and Aspirin under the Treaty of Versailles. That's not just mean, it's a ridiculous level of micromanaging for an international treaty.

No, that's not ridiculous micromanaging for an international peace treaty. Article 282 item 22 of the Versailles Treaty compels Germany to abide by "The Convention of 16 and 19 November 1885 regarding the establishment of a concert pitch".

That is ridiculous micromanaging.


Posted by: ajay | Link to this comment | 05- 9-16 6:41 AM
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The Germans were insisting on having concerts indoors?


Posted by: Moby Hick | Link to this comment | 05- 9-16 6:43 AM
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That's why they kept wanting to expand their living rooms.


Posted by: ajay | Link to this comment | 05- 9-16 6:45 AM
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21: Weren't the Allies seizing a lot of German assets generally for reparations? In that context, it makes sense to include IP assets in the implementation - though it would have been micromanaging if companies/properties were specified by name.


Posted by: Minivet | Link to this comment | 05- 9-16 8:20 AM
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Indeed, perhaps less damaging to the German economy in the short term (wrt hyperinflation, financing costs, etc.) to take reparations in kind rather than in cash.


Posted by: Minivet | Link to this comment | 05- 9-16 8:22 AM
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21 - there's a still (maybe) surprising amount of ongoing effect of the world wars on IP law. Bayer is the most known example (and that still creates issues) but it can come up in figuring out who owns foreign rights to catalog in films or music publishing.


Posted by: R Tigre | Link to this comment | 05- 9-16 8:28 AM
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27, 28 - It's actually "standard pitch" for musical instruments, controlling how instruments are tuned worldwide; previously instruments for sale in the German, English, French, and American markets all used slightly different tuning. They settled on, IIRC, French pitch, and then in the 1970s the ISO returned to something more along the lines of American or German tuning. (This is, believe or not, something I know because it's one of Lyndon LaRouche's hobbyhorses.)


Posted by: snarkout | Link to this comment | 05- 9-16 12:18 PM
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I'll easily believe that it is one of LaRouche's hobbyhorses, but I'm a bit unclear as to why that makes you want to know it.


Posted by: Moby Hick | Link to this comment | 05- 9-16 12:23 PM
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I'll easily believe that it is one of LaRouche's hobbyhorses, but I'm a bit unclear as to why that makes you want to know it.

I was trying to familiarize myself an overview of the craziness while reading this interesting piece on the guy who ran LaRouche's printing operations. Also, I suspect I was avoiding a deadline, which is like 40% of cult recruiting right there. "You mean if I join the Manson Family, I never have to debug this obscure shadow DOM bug? Sign me up, Charlie!"


Posted by: snarkout | Link to this comment | 05- 9-16 12:40 PM
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We used to live in a neighborhood where LaRouchies would regularly hand out leaflets. My wife liked to amuse herself by arguing with them. She said that in the end they thought she was a weirdo, which is probably the finest achievement any of us can hope for in this world or the next.


Posted by: Walt Someguy | Link to this comment | 05- 9-16 12:41 PM
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Bayer is the most known example (and that still creates issues)

And the dueling conglomerates of Merck and Merck KckckKdkcgGkg.


Posted by: Cryptic ned | Link to this comment | 05- 9-16 12:55 PM
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I've taken maybe five Vicodins my entire life (apparently it makes me hyper?) but I am entirely biased towards believing that while there may be many pain patients who are so badly managed they turn into addicts, there is no way that there is absolutely too much pain relief happening, because I know way too many people whose whole life seems to revolve around suffer-suffer-suffer, and most of these people are actually still somewhat healthy.


Posted by: Ile | Link to this comment | 05- 9-16 4:24 PM
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The wild world of accordions has supported approximately 86 bajillion different tunings before, after and during the Treaty of Versailles and all other international agreements. Squeezeboxes are the seed bank of tuning schemes.


Posted by: dairy queen | Link to this comment | 05- 9-16 5:27 PM
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||
Have people seen Avengers: Civil War yet?

My question has literally nothing whatsoever to do with the plot so there are no spoilers.

But that was Xhosa they were speaking, right?* I mean, on the one hand good for them picking an actual language for Wakandans to speak rather than just having them babble Africanish. But Xhosa? We see an actual map of where Wakanda is - it's north of Tanzania, right around Kenya. Having them speak a South African language is just straight up bizarre.

Those countries are really, really far apart! And it's not subtle either - they're using click consonants and everything. They couldn't just have had Swahili with a strange accent or something?

I honestly can't tell if this is "good work" or "Africa is not a f***ing country" territory here.

*I've seen rumors on the internet, and one of the people speaking it is John Kani, and it really, really, really sounds familiar to me. So I certainly believe that it is.

|>


Posted by: MHPH | Link to this comment | 05- 9-16 6:03 PM
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Also at one point T'Challa pronounces "veldt" with a "v" sound, which confused me on at least two different levels.


Posted by: MHPH | Link to this comment | 05- 9-16 6:08 PM
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40: Yes, and the reason is that Kani already spoke it.


Posted by: teofilo | Link to this comment | 05- 9-16 6:25 PM
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Don't anybody tell MHPH that Wakanda doesn't actually exist.


Posted by: politicalfootball | Link to this comment | 05- 9-16 6:56 PM
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I know it doesn't exist. But it doesn't exist in a specific place.


Posted by: MHPH | Link to this comment | 05- 9-16 7:11 PM
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Wait.

If Wakanda doesn't exist, does that mean I can't call Captain America for help expediting my passport renewal?


Posted by: Flippanter | Link to this comment | 05- 9-16 7:29 PM
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There was an interesting thread when helpy-chalk posted the link in 42 at the other place, and the consensus seemed to be that the choice to use Xhosa was positive on net. The apparent location of Wakanda is plausibly within the area where Bantu languages are spoken, and there are even click languages in Tanzania that could theoretically have influenced its language to use clicks.


Posted by: teofilo | Link to this comment | 05- 9-16 7:38 PM
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