Re: Microdosing

1

Now you how to read Michael Pollan's book about really taking LSD.


Posted by: peep | Link to this comment | 07- 5-18 8:33 AM
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2

"Drop acid, not too much, mostly tabs."


Posted by: Moby Hick | Link to this comment | 07- 5-18 8:35 AM
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3

How micro is micro?


Posted by: Mossy Character | Link to this comment | 07- 5-18 8:36 AM
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4

5 micrograms, every third day for a month.


Posted by: heebie-geebie | Link to this comment | 07- 5-18 8:43 AM
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5

A month because experimenting, or because a month just tunes you in permanently?


Posted by: Mossy Character | Link to this comment | 07- 5-18 8:45 AM
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6

1: How did I even write that? I think I have dementia.


Posted by: peep | Link to this comment | 07- 5-18 8:47 AM
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7

Draw an analog clock reading 10:10 and fax it to me. I'll have somebody check.


Posted by: Moby Hick | Link to this comment | 07- 5-18 8:48 AM
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5: A month because experimenting, and then reluctantly discontinued due to the risks of acquiring illegal drugs.


Posted by: heebie-geebie | Link to this comment | 07- 5-18 9:08 AM
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9

But with some optimistic rambling about how this might produce longterm change due to the research that regular LSD can have lifelong therapeutic results from one or two trips.


Posted by: heebie-geebie | Link to this comment | 07- 5-18 9:09 AM
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10

8: Did it make her feel different? I assume she wasn't actually tripping.


Posted by: peep | Link to this comment | 07- 5-18 9:14 AM
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11

Just remembered PKD's dedication, "some people who were punished entirely too much for what they did".


Posted by: Mossy Character | Link to this comment | 07- 5-18 9:16 AM
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12

When a small vial arrives in her mailbox from "Lewis Carroll," Ayelet Waldman is at a low point

Is she actually claiming that it just arrived mysteriously without her doing anything?


Posted by: peep | Link to this comment | 07- 5-18 9:32 AM
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13

On advice of counsel I invoke my rights under the Fifth Amendment.


Posted by: Opinionated Ayelet Waldman | Link to this comment | 07- 5-18 9:35 AM
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14

You only get one amendment per day.


Posted by: Opinionated Homeless Troops | Link to this comment | 07- 5-18 9:44 AM
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10: Yes, she's claiming that she got significant therapeutic benefit, or else significant placebo benefit. Either way, she did well.


Posted by: heebie-geebie | Link to this comment | 07- 5-18 9:44 AM
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12: Nope, she solicited it, but it was the kind of thing where she had a very few lines in the water to actually procure the drugs, and one of them unexpectedly panned out, and the sender did sign it in a cutesy-Lewis-Carroll way.


Posted by: heebie-geebie | Link to this comment | 07- 5-18 9:45 AM
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17

You might want to be careful with characters like that.


Posted by: Opinionated Neo | Link to this comment | 07- 5-18 9:50 AM
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18

I think my literary references like I like my women, wearing skin-tight leather.


Posted by: Moby Hick | Link to this comment | 07- 5-18 9:54 AM
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19

I mean, the good parts were good, but the bad parts, good god. Not a day goes by I don't wonder about that blue pill.


Posted by: Opinionated Neo | Link to this comment | 07- 5-18 9:58 AM
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20

Insert your own "Opinionated Elizabeth Dole" joke.


Posted by: Moby Hick | Link to this comment | 07- 5-18 10:03 AM
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21

What's the supposed mechanism for this hallucinogenic therapy?


Posted by: Mossy Character | Link to this comment | 07- 5-18 10:46 AM
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22

Vascular dilation.


Posted by: Moby Hick | Link to this comment | 07- 5-18 11:04 AM
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23

I seem to recall LSD is a serotonin analogue. How that would have any persistent effect is beyond me.


Posted by: foolishmortal | Link to this comment | 07- 5-18 11:06 AM
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24

21: Something like increasing the plasticity of the brain or something?


Posted by: heebie-geebie | Link to this comment | 07- 5-18 11:09 AM
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25

24: I thought that had to do with mind-blowing qualities of tripping.


Posted by: peep | Link to this comment | 07- 5-18 11:19 AM
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26

Lies your dealer told you.


Posted by: heebie-geebie | Link to this comment | 07- 5-18 11:21 AM
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24: After a lifetime as a dedicated gardener, Michael Pollan finally could hear the plants talking.


Posted by: peep | Link to this comment | 07- 5-18 11:21 AM
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28

As per 23, it's a serotonin agonist, which is the case for most hallucinogens.

I vaguely remember a paper coming out over the last year or two suggesting that its therapeutic effects might come from suppressing default network activity, which could have the effect of weakening well-learned sequences of negative thoughts (like for depressive rumination). I don't know how seriously we're meant to take that explanation though.


Posted by: Swope FM | Link to this comment | 07- 5-18 11:28 AM
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29

Here's what my dealers told me --

A lot of this is a matter of interpretation. There are different ways to explain what's happening in the mind, and it's not clear which one is correct. There's a really interesting researcher at the University of Alabama at Birmingham named Peter Hendricks who is working with cocaine addicts, and he feels that it's the experience of awe that people have on the psychedelic that changes their mindset and gives them a new perspective and allows them to break their addiction.

There's a researcher at UC Berkeley named Dacher Keltner who studies awe, and he suggests that it shrinks the ego, that it results in something he calls the "small self." You're in the presence of something so large that your own sense of self is dwarfed by it. That's a very positive and socially useful emotion. You can reconnect to others after an experience of awe, and he's demonstrated this in a series of interesting experiments. So that's one explanation.

Matt Johnson, one of the researchers at Johns Hopkins, says that we have these stories we tell ourselves about ourselves, and we get stuck on them. We tell ourselves that we're not worthy of love, that we can't get through the next hour without a cigarette, and Johnson thinks these psychedelic experiences shake us out of these patterns because suddenly we see them from a new perspective


Posted by: peep | Link to this comment | 07- 5-18 11:30 AM
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30

If working with cocaine addicts helped people gain knowledge the White House staff wouldn't be so fucked.


Posted by: Moby Hick | Link to this comment | 07- 5-18 11:41 AM
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31

29: Those are three different interpretations?


Posted by: heebie-geebie | Link to this comment | 07- 5-18 12:06 PM
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32

It's all fun and games until Larry "Cocaine" Kudlow runs the National Economic Council.


Posted by: Robert Halford | Link to this comment | 07- 5-18 12:19 PM
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33

My experience with meditation and LSD has been that they shrink the self in similar ways (with meditation you have to work harder, of course) and I'd cautiously sign on to the quotes in 29.

Since the uncool kids ruin every good thing, the latest out here is that LSD has apparently gotten trendy among startup exec types, who are using it liberally to help visualize their disruptions, you know, just like Steve Jobs did.


Posted by: lourdes kayak | Link to this comment | 07- 5-18 12:20 PM
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34

I don't do either meditation or LSD, but I tell myself I'm unworthy of love all the time. Trying to work on that, I guess, but not via meditation or LSD.

(This is just to say I haven't written the next Big Sort summary post but I've half-written it. Maybe tonight I can finish it and toss it into the ether to you!)


Posted by: Thorn | Link to this comment | 07- 5-18 12:24 PM
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35

34.2: What a relief! I was scared that you ate the plums!


Posted by: peep | Link to this comment | 07- 5-18 12:29 PM
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36

Cold water shrinks the self.


Posted by: Moby Hick | Link to this comment | 07- 5-18 12:35 PM
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37

33.2: What happened to just wearing a black turtleneck if you wanted to be like Steve Jobs?

I guess Elizabeth Holmes kind of ruined it.


Posted by: AcademicLurker | Link to this comment | 07- 5-18 12:44 PM
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38

OT: Scott Pruitt resigned to spend more time with his lotion.


Posted by: Moby Hick | Link to this comment | 07- 5-18 12:46 PM
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39

Heard the news from the fake North Korean Twitter account and it was great.


Posted by: foolishmortal | Link to this comment | 07- 5-18 12:55 PM
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40

I don't know about this, because IME I've always spent a significant portion of any acid trip desperately wishing I wasn't tripping, due to the persistent drag of thinking about/seeing myself being rotten and full of worms, or about endless heaps of dead bodies or the like. I would usually try to preƫmpt the madness by purposely thinking of the worst things I could, in the knowledge that one can't sustain any train of thought for long. also, robots or no, sex on acid is reaaaally weird. sure I experienced moments of transcendence, but also long stretches of paralyzing terror. in retrospect I'm wondering why I kept doing it. probably because I wanted to get high. and acid is harsher than mushrooms. maybe try mushrooms? ecstasy?


Posted by: alameida | Link to this comment | 07- 5-18 12:59 PM
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41

29, 33 Same, though I've only experienced that at doses much larger, 250-500 micrograms and larger. I can't imagine having that kind of oceanic experience on a mere 5 micrograms.

40 I've often had the same reaction. Almost all of my trips have been a marriage of heaven and hell. And I do much prefer mushrooms. And DMT.


Posted by: Barry Freed | Link to this comment | 07- 5-18 1:09 PM
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42

41: That's a lot of acid. Maybe don't do so much acid? I also vastly prefer mushrooms though.


Posted by: foolishmortal | Link to this comment | 07- 5-18 1:16 PM
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43

42 That was over 20 years ago, but yeah, that's a lot of acid.


Posted by: Barry Freed | Link to this comment | 07- 5-18 1:20 PM
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44

Even reading the descriptions of people who enjoyed acid, I don't really see the point of acid. Or meditation.


Posted by: Moby Hick | Link to this comment | 07- 5-18 1:34 PM
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45

Never tried acid, but mushrooms were a very pleasant experience.


Posted by: AcademicLurker | Link to this comment | 07- 5-18 1:39 PM
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46

My memories of my LSD trips are almost all positive. No idea of the dosage. I never tried any other psychedelics.


Posted by: peep | Link to this comment | 07- 5-18 1:45 PM
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47

29- I'm sure Douglas Adams had experience with LSD, but he claimed the Total Perspective Vortex drove people mad.


Posted by: SP | Link to this comment | 07- 5-18 1:47 PM
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48

I haven't dropped acid in several decades, but I remember it fondly. The first time I did it (I was probably 18), I was convinced that my brain had been changed forever -- in a good way. Even today, I don't find this belief ridiculous. I like all of peep's 29.


Posted by: politicalfootball | Link to this comment | 07- 5-18 1:54 PM
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49

Keep Scott Pruitt moist, for the love of God!


Posted by: Minivet | Link to this comment | 07- 5-18 2:06 PM
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50

I've always spent a significant portion of any acid trip desperately wishing I wasn't tripping, due to the persistent drag of thinking about/seeing myself being rotten and full of worms, or about endless heaps of dead bodies or the like.

According to Waldman, people who study such things take a lot of care with set and setting. There were researchers priming people on how to solve specific problems they'd been stuck on, priming people to work on their relationships, etc, etc, but bad set-ups make for bad trips and certainly if one's internal mind lends itself to bad trips, I can't imagine it'd be therapeutic.


Posted by: heebie-geebie | Link to this comment | 07- 5-18 2:22 PM
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51

I can't imagine having that kind of oceanic experience on a mere 5 micrograms.

She definitely did not get the oceanic thing. She got a little less irritable and a little more able to roll with life's ups and downs. A little better able to focus on the day after. That kind of thing, but nothing approaching tripping.


Posted by: heebie-geebie | Link to this comment | 07- 5-18 2:24 PM
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52

Like having two beers, but still able to do math correctly?


Posted by: Moby Hick | Link to this comment | 07- 5-18 2:27 PM
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53

A single tab is theoretically around 100 micrograms, I think. I could imagine a 5-microgram dose making you a touch more alert and the world a touch more vivid; I'd also believe that repeated small dosages could correlate with measurable positive effects. But even if it's good for you I don't want it to be utilitarian; I'm still creeped out by the robot thread.


Posted by: lourdes kayak | Link to this comment | 07- 5-18 2:28 PM
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54

One nice thing about macrodosing scotch is that it doesn't come with any accompanying nonsense about how it's somehow good for you.


Posted by: Robert Halford | Link to this comment | 07- 5-18 2:30 PM
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55

dosage varies hugely from batch to batch in my long-ago experience, as does the swill that it's cut with. Stay away from amateur/anonymous chemists, especially when the synthesis is technically demanding, I'd say.

At intermediate doses, stuff like the AI image enhancer that does this seems pretty close. Easy to watch without any associated emotional dislocation or unsettling obsessive ideas. Nobody really knows how all the cells in your body cooperate to keep you alive.


Posted by: lw | Link to this comment | 07- 5-18 2:39 PM
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50 I've always been a fanatic about the proper set and setting but that still didn't prevent my trips from being a mixture of heaven and hell. Maybe my set has always been askew.

48 Same here. Even decades later I still feel like I'm drawing on those experiences.


Posted by: Barry Freed | Link to this comment | 07- 5-18 2:46 PM
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50 I've always been a fanatic about the proper set and setting but that still didn't prevent my trips from being a mixture of heaven and hell. Maybe my set has always been askew.

48 Same here. Even decades later I still feel like I'm drawing on those experiences.


Posted by: Barry Freed | Link to this comment | 07- 5-18 2:46 PM
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58

Trump's in Montana today. Apparently the crowd cheered for Putin.

Are we sure they're not already microdosing us all?


Posted by: CharleyCarp | Link to this comment | 07- 5-18 3:50 PM
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59

Did someone already post this phenazepam thread that lurid found the other day? That stuff is not good for you.


Posted by: lourdes kayak | Link to this comment | 07- 5-18 3:58 PM
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60

It's true that I didn't anticipate how surreal our slide into fascism would seem. Also, I never quite understood how propaganda functioned in the boldfaced lie sense, as opposed to the PSA sense, until the past few years.


Posted by: heebie-geebie | Link to this comment | 07- 5-18 3:58 PM
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61

Did Trump write Pruitt's resignation letter?


Posted by: Moby Hick | Link to this comment | 07- 5-18 4:20 PM
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62

I believe you are serving as President today because of God's providence.

I guess that means Trump didn't win Rhode Island?


Posted by: Moby Hick | Link to this comment | 07- 5-18 4:22 PM
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63

59 is incredible and I'm not even a quarter way done reading that thread.


Posted by: Barry Freed | Link to this comment | 07- 5-18 4:53 PM
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64

Get high on life, hippies!


Posted by: Flippanter | Link to this comment | 07- 5-18 5:15 PM
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65

||

So the short list to replace Kennedy is down to Kavanaugh or Kethledge, because obviously what one K needs is two more.

|>


Posted by: DaveLHI | Link to this comment | 07- 5-18 6:08 PM
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66

Someone must have been telling lies about Brett K., for without having done anything precisely wrong he was chosen one morning to serve on Trump's Supreme Court.


Posted by: lourdes kayak | Link to this comment | 07- 5-18 6:19 PM
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67

I believe you are serving as President today because of God's providence.

That could very well be true.

"I am the punishment of God. If you had not committed great sins, God would not have sent a punishment like me upon you."


Posted by: ajay | Link to this comment | 07- 6-18 1:36 AM
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The thread in 59 links to a description of four nights' ridealong with Ukrainian paramedics which is even better. https://gist.githubusercontent.com/drguildo/2073b2457717f0fc7bec/raw/945d3ee092c10a7fbfc2d26d19231cf96df74eeb/gistfile1.txt


Posted by: ajay | Link to this comment | 07- 6-18 1:55 AM
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67: If he campaigned on that, I'd have more respect for those who voted for him.


Posted by: Moby Hick | Link to this comment | 07- 6-18 5:43 AM
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70

This is why all the tech people need LSD to make it through the day.


Posted by: Moby Hick | Link to this comment | 07- 6-18 5:56 AM
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71

Sounds like an unfogged joose club is in order.


Posted by: Spike | Link to this comment | 07- 6-18 6:57 AM
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71 I read a longer portion of that thread than I care to admit before I realized it was not being anti-Semitic.


Posted by: Barry Freed | Link to this comment | 07- 6-18 7:02 AM
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73

I don't necessarily 100% believe every story on that joose thread.


Posted by: Walt Someguy | Link to this comment | 07- 6-18 8:16 AM
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73 Well, talk about your unreliable narrators...


Posted by: Barry Freed | Link to this comment | 07- 6-18 8:20 AM
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I have been lurking now & again & but I just read the first night of the Ukrainian Ambulance & now I am probably dead.


Posted by: Rah | Link to this comment | 07- 6-18 6:42 PM
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76

Ukrainian Ambulance #3 is fucking wild. I mean it kind of escalates. Don't read Ukrainian Ambulance #4.


Posted by: foolishmortal | Link to this comment | 07- 6-18 6:53 PM
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77

I'll confess I had to pause. Not dinner reading, I am sure.


Posted by: Rah | Link to this comment | 07- 6-18 7:16 PM
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78

I have now read all of Ukrainian Ambulance and the mishmash of farce and tragedy is better than anything Cormac McCarthy ever did.


Posted by: lourdes kayak | Link to this comment | 07- 6-18 8:28 PM
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71: I'm in. I obviously picked the wrong 20-year period to get clean and sober.


Posted by: alameida | Link to this comment | 07- 6-18 8:47 PM
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80

Don't mess with the joose, al.


Posted by: Barry Freed | Link to this comment | 07- 6-18 9:00 PM
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81

in post-soviet ukraine, joose mess with you.


Posted by: alameida | Link to this comment | 07- 6-18 9:22 PM
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